INHIBITORS OF DEUBIQUITINATING ENZYMES INTERFERE WITH THE SARS-COV-2 PAPAIN-LIKE PROTEASE AND BLOCK VIRUS REPLICATION IN VITRO

Inhibitors of Deubiquitinating Enzymes Interfere with the SARS-CoV-2 Papain-like Protease and Block Virus Replication In Vitro

The ubiquitin proteasome system (UPS), particularly its deubiquitinating enzymes (DUBs), play a key role in the replication cycle of coronaviruses.The SARS-CoV-2 papain-like protease (Plpro) is known to process the viral polyproteins to form the replicase transcriptase complex and to counteract the host Life Jackets viral response.Recently, it was

read more


Is resource specialization the key?: some, but not all Red Crossbill call types associate with their key conifers in a diverse North American landscape

Red Crossbills (Fringillidae: Loxia curvirostra) are finches specialized to pry open cones and extract seeds of coniferous trees.Within the species, variable bill morphology may provide more efficient foraging on some species of conifers than others.Subgroups also have distinctly different contact calls often given in flight (hereafter, call types)

read more